News Letter
Information about Bone Cancer

 

Bone cancer is an uncommon cancer that begins in a bone. Bone cancer can begin in any bone in the body, but it most commonly affects the long bones that make up the arms and legs.

 

Several types of Bone cancer exist. The commonest malignant primary bone tumors are the matrix producing tumors, osteosarcoma and chondrosarcoma. Less frequently seen is the small round cell tumor, Ewing’s sarcoma, Malignant fibrous histocytomas, primary bone lymphomas and malignant giant cell tumors are rare but well recognized.

 

The incidence of bone cancer is 1/100 cancer cases  but it contributes to about 6-7% of paediatric cancer patients.

 

Among different types of primary bone cancer, Osteosarcoma constitutes the highest proportion (36%) of cases  followed by chondrosarcoma, osteoclastoma and Ewing's sarcoma.

 

Approach of Rasayu Cancer Clinic towards treatment of Bone cancer largely depends on the stage of cancer. Our first aim in treating Bone cancer is to control pain in patient and prevent complications like bone fracture which can complicate the case and worsen the prognosis. We also target the tumor at the same time and reduces the chances of disease progression and metastatis. Our patients generally show a very significant improvement in symptoms like pain in a span of about 15 days. Majority of our patients are able to manage the pain without any conventional painkillers.

 

Our Rasayana are potent so as to target the tumor cells and also cause tumor regression. While doing this we also ensure to maintain patient’s quality of life. Patients on Rasayana Therapy shows excellent quality of life and also they are able to perform much of their day to day activities.

 

Rasayana also plays an important role in preventing metastasis of the disease. Rasayana therapy have also shown to increase patients survival by many folds as compared to the median survival in patients of that particular stage receiving conventional therapies.

 

Survivors of Bone cancers or patients of other cancers with bone metastasis carries risk of bone fractures. Rasayana significantly reduces chance of developing such complications and keeps the patient healthy.

 

· Bone pain- Pain usually precedes swelling and is typically worse at night.

 

· Swelling and tenderness near the affected area.

 

· Bone fractures.

 

·  Fatigue.

 

· Weight loss, fever, anemia- aggressive tumors may produce this symptoms.

 

Causes and risk factors

  • Genetic- The exact cause of bone tumors is unknown but there is evidence to suggest that it may be due to genetic mutation. The accumulating mutated cells form a mass (tumor) that can invade nearby structures or spread to other areas of the body.

 

  • Inherited genetic syndromes-  Certain rare genetic syndromes passed through families increase the risk of Bone cancer, including Li-Fraumeni syndrome and hereditary retinoblastoma.

 

  • Paget's disease of bone-  Most commonly occurring in older adults, Paget's disease of bone can increase the risk of Bone cancer developing later. Osteosarcoma  mostly occurs due to complication of Paget's disease.

 

  • Radiation therapy for cancer- Exposure to large doses of radiation such as those given during radiation therapy for cancer, increases the risk of Bone cancer in the future. The risks of radiation induced sarcoma are much greater in children than adult.

 

  • Other - Bone Infarction chronic osteomyelitis and the presence of metal prostheses have also been linked to bone sarcoma development.

 

X-ray- In most cases the investigations begin with plain X-rays of the affected bone.

 

Bone scan/ Computerized tomography (CT)/ Magnetic resonance imaging (MRI)/ Positron emission tomography (PET)-   The exact extent of the lesion and the presence of vascular or neurological invasion must be clarified by scanning.

 

Biopsy- For definitive diagnosis doctor advised a procedure to remove a sample of tissue (biopsy) from the tumor for laboratory testing. An excision biopsy may appropriate for small easily accessible and benign looking lesions but in most cases a core needle biopsy is performed. Incisional biopsies run the risk of spreading tumor cells within the field of the incision and are avoided if possible.

 

Histopathology- Conventional histopathological techniques using light microscopy and cytogenetics may occasionally be needed . An isotope bone scan is performed for search of skip lesions within the affected bone and distant bone metastasis.

 

 

The treatment options for Bone cancer are based on the type of cancer the stage of the cancer and overall health. Most patients will require treatment involving a combination of surgery, radiotherapy and /or chemotherapy.

 

Surgery

 

Surgery may be the first therapeutic procedure undertaken or it may be preceded by chemotherapy in an effort to improve the respectability of the tumor.

 

Types of surgery used to treat Bone cancer include:

Surgery to remove the cancer but spare the limb-  If a Bone cancer can be separated from nerves and other tissue the surgeon may be able to remove the Bone cancer and spare the limb. The principles of limb – sparing sarcoma surgery are now well established.

 

Surgery for cancer that doesn't affect the limbs- If Bone cancer occurs in bones other than those of the arms and legs, surgeons may remove the bone and some surrounding tissue. Unfortunately many bone tumors arise near joints which may need to be excised and replaced by artificial ones.

 

Surgery to remove a limb - Most of the time bone tumors may require surgery to remove all or part of a limb (amputation) and replaced by artificial limb (prosthesis).

 

Radiotherapy- Radiotherapy is used to treat unresectable tumors or to reduce the risk of recurrence postoperatively in certain circumstances. Most patients will experience acute radiation skin reactions. Long term abnormalities of growth and limb function are seen in younger patients if growth in the irradiated limb is not complete.

 

Chemotherapy- Chemotherapy can be used to treat Bone cancers. Various regimens are available according to types of bone tumors. VIDE-Regimen (Vincristine, Ifosfamide, Doxorubicin, Etoposide) can be used for Ewing’s sarcoma. Cisplatin, doxorubicin, methotreaxate are commonly used to treat  osteosarcoma and spindle cell sarcomas.

 

Global Appointment
Dubai

Dr. Bendale will be soon available at Dubai for offering consultation to patients.Patients desirous of having an appointment can contact us at following mail id care@rasayucancerclinic.com

Netherland and Belgium

Dr. Bendale will be soon available at Netherland for offering consultation to patients.Patients desirous of having an appointment can contact us at following mail id care@rasayucancerclinic.com

London

Dr. Bendale will be soon available at London for offering consultation to patients.Patients desirous of having an appointment can contact us at following mail id care@rasayucancerclinic.com