News Letter
Information about Renal Cell Carcinoma

 

Renal cell carcinoma is a cancer of kidneys which occurs when cancer cells start growing in the lining of kidney tubules. Excretion of waste products and formation of urine is a major function done by of kidneys in our body. Renal cell carcinoma (RCC) accounts for 3% of all adult malignancies. Renal cell carcinoma is commonest tumors of the kidney. It is arise from proximal renal tubular cells. RCC is more common in males between the ages of 50 and 70 (male: female ratio 2:1) but can be diagnosed in anyone. The incidence of RCC has increased by 38% in last two decades. At the time of diagnosis, about 20% patients have metastatic carcinoma and 25% have totally advanced disease.

 

Our main therapeutic approach in Renal cell carcinoma differs as per the stage of the disease.

 

Our medicines are planned such that it will minimize patients suffering in a short span of just few weeks. Along with this our medicines helps modify disease causing factors in patient’s body thereby reducing the chance of relapse or metastasis. Our treatment successfully increases patient’s survival by several folds and stimulates immunity to cause tumor regression.

 

RCC is detected as an asymptomatic incidental lesion in at least 20% cases. Cinical presentation of RCC is variable. In at least 20% case are found incidental and in asymptomatic stage. In early stage it may be symptom free.

 

Following symptoms may occur with progression of disease.

  Hematuria - blood in the urine.

  Loin pain with or without mass.

  Lump in the abdomen.

  Fever of unknown origin.

  Malaise.

  Hematological disorders- Anemia, Thrombocytopenia.

  Unexplained weight loss.

  Loss of appetite.

  Fatigue.

  Vision problems.

  Persistent pain in the side.

  Erythrocytosis.

  Hypercalcemia.

  Hypertension – incidence up to 40%.

  Hepatic dysfunction-Uncommon.

  Raised alkaline phosphatase.

 Hypergammaglobulinaemia.

 Raised bilirubin.

 Hypoalbubiminaemia.

  Prolonged prothrombin time.

  Cushing’s syndrome-rare.

  Protein Enteropathy.

  Galactorrhoea.

  Hypoglycemia.

 

The exact cause of disease is unknown but there are some risk factors for the disease including:

 

Family history of RCC.

Dialysis treatment.

Hypertension.

Smoking cigarettes.

Polycystic kidney disease.

Von Hippel-Lindau syndrome (VHL)-associated with chromosomal mutations and at high risk in their 30s for development of RCC.

Acquired renal cystic disease from uraemia.

Chronic abuse of some medications such as non-steroidal anti-inflammatory drugs used to treat arthritis and medications   for fever and pain relief such as acetaminophen.

Hoarseshoe kidneys. 

A complete blood count, a blood test , its frequently demonstrate anemia and raised ESR.

 

ACT scan or MRI an imaging test that will assess kidney tumor growth and its extension in your body. These tests are more sensitive than USS.

 

Abdominal and kidney ultrasounography.

 

Urine examination, tests used to detect blood in the urine and to analyze cell in the urine looking for evidence of cancer.

 

Echocardiography-It may be needed if there is evidence of atrial involvement.

 

Venography- to assess thrombus.

 

Biopsy- Your doctor may also perform a biopsy to get a small piece of kidney tissue to rule out or confirm the presence of cancer. It is not routinely recommended as it can be inconclusive.

 

Screening tests-PET scan, chest X-ray, bone scan to rule out spread of disease anywhere in your body.

 

There are five kinds of standard treatment for RCC: surgery, radiation therapy, chemotherapy, biologic therapy and targeted therapy. One or more may be used to treat your cancer according to the stage of the disease.

 

Treatment of Localized RCC

 

Surgery-The mainstay of treatment of RCC is radical treatment with excision of kidney. Depending on how far the disease has spread, more extensive surgery may be needed to remove surrounding tissue, lymph nodes and the adrenal gland.

 

Surgery can include different types of procedures.

 

Partial nephrectomy - Part of the kidney or the entire kidney may be removed;

Radical neprectomy- complete removal of kidney.

 

Treatment of metastatic RCC –Some patients will present with a solitary metastatic lesion in the Lung or brain. Selection of treatments depends on symptoms and extension of spread of disease.

 

Immunotherapy-RCC exhibits multidrug resistance and at presents no useful chemotherapy –only regimens exist for treatment. Interferon-alpha and interleukin -2 these two components are available. Side effects of this includes fevers, chills, malaise, nausea and vomiting.

 

Nephron sparing surgery- Occasionally patients develop bilateral renal cell cancer or may have had previous nephrectomy damage to the other kidney. In these circumstances this surgery may be considered.

 

Radiation-Radiation therapy involves using high-energy X-rays to kill cancer cells.

 

Targeted Therapy-Targeted therapy is a newer kind of cancer drug therapy. These drugs attack certain cancer cells without damaging healthy cells. 

Global Appointment
Dubai

Dr. Bendale will be soon available at Dubai for offering consultation to patients.Patients desirous of having an appointment can contact us at following mail id care@rasayucancerclinic.com

Netherland and Belgium

Dr. Bendale will be soon available at Netherland for offering consultation to patients.Patients desirous of having an appointment can contact us at following mail id care@rasayucancerclinic.com

London

Dr. Bendale will be soon available at London for offering consultation to patients.Patients desirous of having an appointment can contact us at following mail id care@rasayucancerclinic.com